Researchers
Name (Institute) |
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| Specialty | Quantitative systems pharmacology Precision medicine Cancer biology Single-cell dynamics |
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| Science Interest (Past) |
I was trained in the Medical Engineering and Medical Physics by the Harvard-MIT Division of Health Science and Technology. My Ph.D. work was on micropatterning technology for studying the autocrine signaling in cancer and stem cells. I then moved on to join Peter Sorger lab at Harvard Medical school in the Systems Biology department. My work there focused on live single-cell dynamics of oncogenic pathways. I studied how single-cell dynamics of MAPK and AKT pathways contributes towards heterogeneity of drug response in breast cancer cells. | ||||
| Science Interest (Current) |
Currently, my laboratory focuses on 3 main areas. First, we developed and implemented biosensor platforms for exploring therapeutic sciences in various diseases. Some of these novel sensors include FoxO3, FoxM1, NRF2 and we also used available sensors for MAPK, NFKB, p38, JNK for studies biological responses of both chemical compounds as well as natural extracts/recipes. Second, we develop cancer avatar models for studying cancer and for developing novel predictive biomarkers. We tried to implement these models for developing novel therapeutic strategies. Finally, we also develop multiplex diagnostic platforms for disease prediction as well as pro-health monitoring. | ||||
| Science Interest (Future) |
I am interested in translating the resources we have in the lab towards clinical applications. Currently, we are incorporating reverse-phase protein array as well as digital pathology analysis into our workflow. These platforms will help enable assessment of archival specimens from patients. We are also interested to expand our lab capability of cancer avatar models into other cancer types. | ||||
| Website / Contact | https://www.sisyspharm.org/en/ |
