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An international platform for discovery of novel chemotypes against flaviviral infection |
| Principal Investigator / Affiliation | Sarin Chimnaronk (Assistant Professor) / Mahidol University  Thailand |
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Ryuichi Sakai (Professor) / Hokkaido University  Japan |
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Daniel Romo (Schotts Professor of Chemistry) / Baylor University  USA |
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| Year Adopted | 2019 |
| Research Period | 2020 - 2023 |
| General Description of the Research Project | This research project will establish a unique and modern pipeline for novel drug lead discovery for flaviviruses including dengue and Zika viruses. Goals of the project include collection of bioactive libraries from marine organisms, establishment of reliable high-throughput bioassays, structural and phenotypic validation of mechanisms of action, and chemical synthesis and modifications to identify pharmacophores and improve potency and selectivity. |
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Researchers
| Principal Investigator / Country of Research Team | 
Ryuichi Sakai Japan
Daniel Romo the United States |
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