Researchers
Name (Institute) |
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| Specialty | Medicinal Chemistry
Drug development Lead Drug Identification and Optimization Fragment drug screening Structure-Based Drug Design Probe Synthesis Synthetic Organic Chemistry Antibody-Drug Conjugates |
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| Science Interest (Past) |
As a graduate student and post-doctoral associate, I conducted research that led to the development of novel synthetic methods and the total synthesis of 5 natural products. As a graduate student, I developed novel synthetic methodology for the synthesis of fused carbocyclic systems (6-, 7- and 8-membered rings) through intramolecular additions of allylsilanes to conjugated dienones. This methodology was then used to synthesize 4 natural products including the marine sesquiterpene neolemnane. My post-doctoral research focused on the total synthesis of the antitumor metabolite Calyculin A, which is a potent inhibitor of serine/threonine protein phosphatase types 1 and 2A. I have worked for over 20 years as a medicinal chemist in the pharmaceutical industry and 8 years as assistant director of the CPRIT synthesis and drug-lead discovery lab at Baylor University. | ||||
| Science Interest (Current) |
My Current interests are in medicinal chemistry, probe synthesis for target identification studies and synthetic method development. I'm also very interested in working in therapeutic areas with high unmet medical need such as oncology and infectious disease. Natural product research and synthesis are also of interest. | ||||
| Science Interest (Future) |
Same as present. | ||||
| Website / Contact | https://baylorcpritlab.com |
